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Systematic name YLR396C
Gene name VPS33
Aliases CLS14, MET27, PEP14, SLP1, VAM5, VPL25, VPT33
Feature type ORF, Verified
Coordinates Chr XII:912310..910235
Primary SGDID S000004388

Description of YLR396C: ATP-binding protein that is a subunit of the HOPS complex and of the CORVET tethering complex; essential for protein sorting, vesicle docking and fusion at the vacuole[1][2][3][4]


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  1. Darsow T, et al. (1997) A multispecificity syntaxin homologue, Vam3p, essential for autophagic and biosynthetic protein transport to the vacuole. J Cell Biol 138(3):517-29 SGD PMID 9245783
  2. Gerhardt B, et al. (1998) The vesicle transport protein Vps33p is an ATP-binding protein that localizes to the cytosol in an energy-dependent manner. J Biol Chem 273(25):15818-29 SGD PMID 9624182
  3. Peplowska K, et al. (2007) The CORVET Tethering Complex Interacts with the Yeast Rab5 Homolog Vps21 and Is Involved in Endo-Lysosomal Biogenesis. Dev Cell 12(5):739-50 SGD PMID 17488625
  4. Seals DF, et al. (2000) A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion. Proc Natl Acad Sci U S A 97(17):9402-7 SGD PMID 10944212

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