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Systematic name YLR320W
Gene name MMS22
Aliases SLM2
Feature type ORF, Verified
Coordinates Chr XII:771940..776304
Primary SGDID S000004312

Description of YLR320W: Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork, such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; required for accurate meiotic chromosome segregation[1][2][3][4][5]


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  1. Araki Y, et al. (2003) Budding yeast mcm10/dna43 mutant requires a novel repair pathway for viability. Genes Cells 8(5):465-80 SGD PMID 12694535
  2. Bennett CB, et al. (2001) Genes required for ionizing radiation resistance in yeast. Nat Genet 29(4):426-34 SGD PMID 11726929
  3. Duro E, et al. (2008) Budding yeast Mms22 and Mms1 regulate homologous recombination induced by replisome blockage. DNA Repair (Amst) 7(5):811-8 SGD PMID 18321796
  4. Jordan PW, et al. (2007) Novel roles for selected genes in meiotic DNA processing. PLoS Genet 3(12):e222 SGD PMID 18069899
  5. Vaisica JA, et al. (2011) Mms1 and Mms22 stabilize the replisome during replication stress. Mol Biol Cell 22(13):2396-408 SGD PMID 21593207

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