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Systematic name YLR299W
Gene name ECM38
Aliases CIS2
Feature type ORF, Verified
Coordinates Chr XII:726069..728051
Primary SGDID S000004290

Description of YLR299W: Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation[1][2][3][4]


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DNA and RNA Details

Other DNA and RNA Details

Other Topic: expression

Specifically higher expression in nitrogen limited chemostat cultures versus nitrogen excess. [5] [6]



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  1. Kumar C, et al. (2003) Investigations into the polymorphisms at the ECM38 locus of two widely used Saccharomyces cerevisiae S288C strains, YPH499 and BY4742. Yeast 20(10):857-63 SGD PMID 12868055
  2. Kumar C, et al. (2003) Utilization of glutathione as an exogenous sulfur source is independent of gamma-glutamyl transpeptidase in the yeast Saccharomyces cerevisiae: evidence for an alternative gluathione degradation pathway. FEMS Microbiol Lett 219(2):187-94 SGD PMID 12620619
  3. Springael JY and Penninckx MJ (2003) Nitrogen-source regulation of yeast gamma-glutamyl transpeptidase synthesis involves the regulatory network including the GATA zinc-finger factors Gln3, Nil1/Gat1 and Gzf3. Biochem J 371(Pt 2):589-95 SGD PMID 12529169
  4. Ubiyvovk VM, et al. (2006) Role of gamma-glutamyltranspeptidase in detoxification of xenobiotics in the yeasts Hansenula polymorpha and Saccharomyces cerevisiae. Cell Biol Int 30(8):665-71 SGD PMID 16857395
  5. Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
  6. submitted by Viktor Boer on 2003-07-25

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