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Systematic name YLR234W
Gene name TOP3
Aliases EDR1
Feature type ORF, Verified
Coordinates Chr XII:609783..611753
Primary SGDID S000004224

Description of YLR234W: DNA Topoisomerase III, conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially, involved in telomere stability and regulation of mitotic recombination[1][2][3][4][5]


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  1. Bailis AM, et al. (1992) Genome rearrangement in top3 mutants of Saccharomyces cerevisiae requires a functional RAD1 excision repair gene. Mol Cell Biol 12(11):4988-93 SGD PMID 1328869
  2. Bennett RJ, et al. (2000) Interaction between yeast sgs1 helicase and DNA topoisomerase III. J Biol Chem 275(35):26898-905 SGD PMID 10862619
  3. Chang M, et al. (2005) RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex. EMBO J 24(11):2024-33 SGD PMID 15889139
  4. Kim RA and Wang JC (1992) Identification of the yeast TOP3 gene product as a single strand-specific DNA topoisomerase. J Biol Chem 267(24):17178-85 SGD PMID 1324925
  5. Kim RA, et al. (1995) Effects of yeast DNA topoisomerase III on telomere structure. Proc Natl Acad Sci U S A 92(7):2667-71 SGD PMID 7708702

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