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Systematic name YLR193C
Gene name UPS1
Feature type ORF, Verified
Coordinates Chr XII:540536..540009
Primary SGDID S000004183

Description of YLR193C: Mitochondrial protein involved in phospholipid metabolism; localizes to the intermembrane space; has a role in regulation of phospholipid metabolism by promoting conversion of phosphatidylethanolamine to phosphatidylcholine; null mutant has altered cardiolipin and phosphatidylethanolamine levels and defects in Mgm1p processing, integrity of mitochondrial inner membrane complexes, and mitochondrial morphology; ortholog of human PRELI[1][2][3][4]


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  1. Osman C, et al. (2009) The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria. J Cell Biol 184(4):583-96 SGD PMID 19221197
  2. Sesaki H, et al. (2006) Ups1p, a conserved intermembrane space protein, regulates mitochondrial shape and alternative topogenesis of Mgm1p. J Cell Biol 173(5):651-8 SGD PMID 16754953
  3. Tamura Y, et al. (2009) Ups1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochondria. J Cell Biol 185(6):1029-45 SGD PMID 19506038
  4. Tamura Y, et al. (2012) Role for two conserved intermembrane space proteins, Ups1p and Up2p, in intra-mitochondrial phospholipid trafficking. J Biol Chem () SGD PMID 22403410

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