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Systematic name YLR176C
Gene name RFX1
Aliases CRT1
Feature type ORF, Verified
Coordinates Chr XII:510232..507797
Primary SGDID S000004166

Description of YLR176C: Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins[1][2][3]


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  1. Emery P, et al. (1996) RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom. Nucleic Acids Res 24(5):803-7 SGD PMID 8600444
  2. Huang M, et al. (1998) The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor. Cell 94(5):595-605 SGD PMID 9741624
  3. Woolstencroft RN, et al. (2006) Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length. J Cell Sci 119(Pt 24):5178-92 SGD PMID 17158920

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