YLR148W

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Systematic name YLR148W
Gene name PEP3
Aliases VAM8, VPS18, VPT18
Feature type ORF, Verified
Coordinates Chr XII:434641..437397
Primary SGDID S000004138


Description of YLR148W: Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis[1][2][3][4]




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References

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  1. Peplowska K, et al. (2007) The CORVET Tethering Complex Interacts with the Yeast Rab5 Homolog Vps21 and Is Involved in Endo-Lysosomal Biogenesis. Dev Cell 12(5):739-50 SGD PMID 17488625
  2. Preston RA, et al. (1991) Isolation and characterization of PEP3, a gene required for vacuolar biogenesis in Saccharomyces cerevisiae. Mol Cell Biol 11(12):5801-12 SGD PMID 1944264
  3. Robinson JS, et al. (1991) A putative zinc finger protein, Saccharomyces cerevisiae Vps18p, affects late Golgi functions required for vacuolar protein sorting and efficient alpha-factor prohormone maturation. Mol Cell Biol 11(12):5813-24 SGD PMID 1840635
  4. Srivastava A, et al. (2000) Pep3p/Pep5p complex: a putative docking factor at multiple steps of vesicular transport to the vacuole of Saccharomyces cerevisiae. Genetics 156(1):105-22 SGD PMID 10978279

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