YLR021W

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Systematic name YLR021W
Gene name IRC25
Aliases DMP2, PBA3, POC3
Feature type ORF, Verified
Coordinates Chr XII:183623..184162
Primary SGDID S000004011


Description of YLR021W: Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions[1][2][3][4]




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References

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  1. Alvaro D, et al. (2007) Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination. PLoS Genet 3(12):e228 SGD PMID 18085829
  2. Kusmierczyk AR, et al. (2008) A multimeric assembly factor controls the formation of alternative 20S proteasomes. Nat Struct Mol Biol 15(3):237-44 SGD PMID 18278055
  3. Le Tallec B, et al. (2007) 20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals. Mol Cell 27(4):660-74 SGD PMID 17707236
  4. Yashiroda H, et al. (2008) Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes. Nat Struct Mol Biol 15(3):228-36 SGD PMID 18278057

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