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Systematic name YLL016W
Gene name SDC25
Feature type pseudogene
Coordinates Chr XII:112847..115993
Primary SGDID S000003939

Description of YLL016W: Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL017W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication[1][2][3][4][5]


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  1. Boy-Marcotte E, et al. (1989) The C-terminal part of a gene partially homologous to CDC 25 gene suppresses the cdc25-5 mutation in Saccharomyces cerevisiae. Gene 77(1):21-30 SGD PMID 2545538
  2. Boy-Marcotte E, et al. (1996) SDC25, a dispensable Ras guanine nucleotide exchange factor of Saccharomyces cerevisiae differs from CDC25 by its regulation. Mol Biol Cell 7(4):529-39 SGD PMID 8730097
  3. Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 SGD PMID 16169922
  4. Crechet JB, et al. (2000) Analysis of the role of the hypervariable region of yeast Ras2p and its farnesylation in the interaction with exchange factors and adenylyl cyclase. J Biol Chem 275(23):17754-61 SGD PMID 10747953
  5. Damak F, et al. (1991) SDC25, a CDC25-like gene which contains a RAS-activating domain and is a dispensable gene of Saccharomyces cerevisiae. Mol Cell Biol 11(1):202-12 SGD PMID 1986220

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