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Systematic name YKR095W
Gene name MLP1
Aliases MPL1
Feature type ORF, Verified
Coordinates Chr XI:619805..625432
Primary SGDID S000001803

Description of YKR095W: Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs[1][2][3][4][5]


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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [6] [7]



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  1. Galy V, et al. (2004) Nuclear retention of unspliced mRNAs in yeast is mediated by perinuclear Mlp1. Cell 116(1):63-73 SGD PMID 14718167
  2. Hediger F, et al. (2002) Myosin-like proteins 1 and 2 are not required for silencing or telomere anchoring, but act in the Tel1 pathway of telomere length control. J Struct Biol 140(1-3):79-91 SGD PMID 12490156
  3. Kolling R, et al. (1993) A new yeast gene with a myosin-like heptad repeat structure. Mol Gen Genet 237(3):359-69 SGD PMID 8483450
  4. Palancade B, et al. (2005) Pml39, a novel protein of the nuclear periphery required for nuclear retention of improper messenger ribonucleoparticles. Mol Biol Cell 16(11):5258-68 SGD PMID 16162818
  5. Strambio-de-Castillia C, et al. (1999) Proteins connecting the nuclear pore complex with the nuclear interior. J Cell Biol 144(5):839-55 SGD PMID 10085285
  6. Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  7. submitted by Jeff Ubersax on 2004-01-29

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