YKR082W

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Systematic name YKR082W
Gene name NUP133
Aliases RAT3
Feature type ORF, Verified
Coordinates Chr XI:592825..596298
Primary SGDID S000001790


Description of YKR082W: Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP133[1][2][3][4][5][6][7][8][9]




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References

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  1. Allen NP, et al. (2002) Deciphering networks of protein interactions at the nuclear pore complex. Mol Cell Proteomics 1(12):930-46 SGD PMID 12543930
  2. Fernandez-Martinez J and Rout MP (2009) Nuclear pore complex biogenesis. Curr Opin Cell Biol 21(4):603-12 SGD PMID 19524430
  3. Fernandez-Martinez J, et al. (2012) Structure-function mapping of a heptameric module in the nuclear pore complex. J Cell Biol () SGD PMID 22331846
  4. Gao H, et al. (2003) Nuclear accumulation of the small GTPase Gsp1p depends on nucleoporins Nup133p, Rat2p/Nup120p, Nup85p, Nic96p, and the acetyl-CoA carboxylase Acc1p. J Biol Chem 278(28):25331-40 SGD PMID 12730220
  5. Lutzmann M, et al. (2002) Modular self-assembly of a Y-shaped multiprotein complex from seven nucleoporins. EMBO J 21(3):387-97 SGD PMID 11823431
  6. Rout MP, et al. (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J Cell Biol 148(4):635-51 SGD PMID 10684247
  7. Sarma NJ, et al. (2011) The nuclear pore complex mediates binding of the mig1 repressor to target promoters. PLoS One 6(11):e27117 SGD PMID 22110603
  8. Therizols P, et al. (2006) Telomere tethering at the nuclear periphery is essential for efficient DNA double strand break repair in subtelomeric region. J Cell Biol 172(2):189-99 SGD PMID 16418532
  9. Tous C, et al. (2011) A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors. EMBO J 30(10):1953-64 SGD PMID 21478823

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