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Systematic name YKR059W
Gene name TIF1
Feature type ORF, Verified
Coordinates Chr XI:554987..556174
Primary SGDID S000001767

Description of YKR059W: Translation initiation factor eIF4A, identical to Tif2p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G[1][2][3][4]


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  1. Blum S, et al. (1989) Translation in Saccharomyces cerevisiae: initiation factor 4A-dependent cell-free system. Proc Natl Acad Sci U S A 86(16):6043-6 SGD PMID 2668952
  2. Caruthers JM, et al. (2000) Crystal structure of yeast initiation factor 4A, a DEAD-box RNA helicase. Proc Natl Acad Sci U S A 97(24):13080-5 SGD PMID 11087862
  3. Chang TH, et al. (1990) Identification of five putative yeast RNA helicase genes. Proc Natl Acad Sci U S A 87(4):1571-5 SGD PMID 2406722
  4. Neff CL and Sachs AB (1999) Eukaryotic translation initiation factors 4G and 4A from Saccharomyces cerevisiae interact physically and functionally. Mol Cell Biol 19(8):5557-64 SGD PMID 10409745

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