YKR038C
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| Systematic name | YKR038C |
| Gene name | KAE1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XI:513159..511999 |
| Primary SGDID | S000001746 |
Description of YKR038C: Highly conserved ATPase of HSP70/DnaK family; component of the EKC/KEOPS complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription[1][2][3][4][5][6]
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References
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- ↑ Daugeron MC, et al. (2011) Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs. Nucleic Acids Res 39(14):6148-60 SGD PMID 21459853
- ↑ Downey M, et al. (2006) A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator. Cell 124(6):1155-68 SGD PMID 16564010
- ↑ Kisseleva-Romanova E, et al. (2006) Yeast homolog of a cancer-testis antigen defines a new transcription complex. EMBO J 25(15):3576-85 SGD PMID 16874308
- ↑ Lopreiato R, et al. (2004) Analysis of the interaction between piD261/Bud32, an evolutionarily conserved protein kinase of Saccharomyces cerevisiae, and the Grx4 glutaredoxin. Biochem J 377(Pt 2):395-405 SGD PMID 14519092
- ↑ Oberto J, et al. (2009) Qri7/OSGEPL, the mitochondrial version of the universal Kae1/YgjD protein, is essential for mitochondrial genome maintenance. Nucleic Acids Res 37(16):5343-52 SGD PMID 19578062
- ↑ Srinivasan M, et al. (2011) The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A. EMBO J 30(5):873-81 SGD PMID 21183954
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