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Systematic name YKL010C
Gene name UFD4
Feature type ORF, Verified
Coordinates Chr XI:425875..421424
Primary SGDID S000001493

Description of YKL010C: Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins[1][2][3]


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  1. Hochstrasser M (1996) Ubiquitin-dependent protein degradation. Annu Rev Genet 30:405-39 SGD PMID 8982460
  2. Xie Y and Varshavsky A (2000) Physical association of ubiquitin ligases and the 26S proteasome. Proc Natl Acad Sci U S A 97(6):2497-502 SGD PMID 10688918
  3. Xie Y and Varshavsky A (2002) UFD4 lacking the proteasome-binding region catalyses ubiquitination but is impaired in proteolysis. Nat Cell Biol 4(12):1003-7 SGD PMID 12447385

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