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Systematic name YKL002W
Gene name DID4
Aliases CHM2, GRD7, REN1, VPL2, VPS14, VPS2, VPT14
Feature type ORF, Verified
Coordinates Chr XI:437778..438544
Primary SGDID S000001485

Description of YKL002W: Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis[1][2][3][4]


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  1. Amerik AY, et al. (2000) The Doa4 deubiquitinating enzyme is functionally linked to the vacuolar protein-sorting and endocytic pathways. Mol Biol Cell 11(10):3365-80 SGD PMID 11029042
  2. Babst M, et al. (2002) Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting. Dev Cell 3(2):271-82 SGD PMID 12194857
  3. Davis NG, et al. (1993) Cis- and trans-acting functions required for endocytosis of the yeast pheromone receptors. J Cell Biol 122(1):53-65 SGD PMID 8391002
  4. Odorizzi G, et al. (2003) Bro1 is an endosome-associated protein that functions in the MVB pathway in Saccharomyces cerevisiae. J Cell Sci 116(Pt 10):1893-903 SGD PMID 12668726

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