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Systematic name YJR119C
Gene name JHD2
Aliases KDM5
Feature type ORF, Verified
Coordinates Chr X:646490..644304
Primary SGDID S000003880

Description of YJR119C: JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation[1][2][3][4]


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  1. Liang G, et al. (2007) Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase. Nat Struct Mol Biol 14(3):243-5 SGD PMID 17310254
  2. Mersman DP, et al. (2009) Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression. Genes Dev 23(8):951-62 SGD PMID 19346402
  3. Seward DJ, et al. (2007) Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins. Nat Struct Mol Biol 14(3):240-2 SGD PMID 17310255
  4. Tu S, et al. (2007) Identification of histone demethylases in Saccharomyces cerevisiae. J Biol Chem 282(19):14262-71 SGD PMID 17369256

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