YJR089W

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Systematic name YJR089W
Gene name BIR1
Aliases
Feature type ORF, Verified
Coordinates Chr X:587718..590582
Primary SGDID S000003849


Description of YJR089W: Subunit of chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates chromosome segregation; required for chromosome bi-orientation and for spindle assembly checkpoint activation upon reduced sister kinetochore tension[1][2][3][4]




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References

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  1. Li F, et al. (2000) Cell division regulation by BIR1, a member of the inhibitor of apoptosis family in yeast. J Biol Chem 275(10):6707-11 SGD PMID 10702224
  2. Makrantoni V and Stark MJ (2009) Efficient chromosome biorientation and the tension checkpoint in Saccharomyces cerevisiae both require Bir1. Mol Cell Biol 29(16):4552-62 SGD PMID 19528231
  3. Nakajima Y, et al. (2009) Nbl1p: a Borealin/Dasra/CSC-1-like protein essential for Aurora/Ipl1 complex function and integrity in Saccharomyces cerevisiae. Mol Biol Cell 20(6):1772-84 SGD PMID 19158380
  4. Yoon HJ and Carbon J (1999) Participation of Bir1p, a member of the inhibitor of apoptosis family, in yeast chromosome segregation events. Proc Natl Acad Sci U S A 96(23):13208-13 SGD PMID 10557299

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