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Systematic name YJR066W
Gene name TOR1
Aliases DRR1
Feature type ORF, Verified
Coordinates Chr X:559416..566828
Primary SGDID S000003827

Description of YJR066W: PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis[1][2][3][4][5][6][7][8][9][10]


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Regulatory interaction with YBL064c
PRX1 mRNA expression is down regulated by TOR1p in the presence of glucose. [11] [12]



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  1. Barbet NC, et al. (1996) TOR controls translation initiation and early G1 progression in yeast. Mol Biol Cell 7(1):25-42 SGD PMID 8741837
  2. Beck T and Hall MN (1999) The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature 402(6762):689-92 SGD PMID 10604478
  3. Cardenas ME, et al. (1999) The TOR signaling cascade regulates gene expression in response to nutrients. Genes Dev 13(24):3271-9 SGD PMID 10617575
  4. Kamada Y, et al. (2000) Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol 150(6):1507-13 SGD PMID 10995454
  5. Loewith R, et al. (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 10(3):457-68 SGD PMID 12408816
  6. Lorberg A and Hall MN (2004) TOR: the first 10 years. Curr Top Microbiol Immunol 279():1-18 SGD PMID 14560948
  7. Martin DE, et al. (2004) TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1. Cell 119(7):969-79 SGD PMID 15620355
  8. Powers T and Walter P (1999) Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae. Mol Biol Cell 10(4):987-1000 SGD PMID 10198052
  9. Torres J, et al. (2002) Regulation of the cell integrity pathway by rapamycin-sensitive TOR function in budding yeast. J Biol Chem 277(45):43495-504 SGD PMID 12171921
  10. Zheng XF and Schreiber SL (1997) Target of rapamycin proteins and their kinase activities are required for meiosis. Proc Natl Acad Sci U S A 94(7):3070-5 SGD PMID 9096347
  11. Monteiro G and Netto LE (2004) Glucose repression of PRX1 expression is mediated by Tor1p and Ras2p through inhibition of Msn2/4p in Saccharomyces cerevisiae. FEMS Microbiol Lett 241(2):221-8 SGD PMID 15598536
  12. submitted by Gisele Monteiro on 2005-01-03

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