YJR060W
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| Systematic name | YJR060W |
| Gene name | CBF1 |
| Aliases | CEP1, CPF1 |
| Feature type | ORF, Verified |
| Coordinates | Chr X:548759..549814 |
| Primary SGDID | S000003821 |
Description of YJR060W: Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation[1][2][3][4][5][6][7]
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Community Commentary
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References
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- ↑ Cai M and Davis RW (1990) Yeast centromere binding protein CBF1, of the helix-loop-helix protein family, is required for chromosome stability and methionine prototrophy. Cell 61(3):437-46 SGD PMID 2185892
- ↑ Kent NA, et al. (2004) Cbf1p is required for chromatin remodeling at promoter-proximal CACGTG motifs in yeast. J Biol Chem 279(26):27116-23 SGD PMID 15111622
- ↑ Kuras L, et al. (1996) A heteromeric complex containing the centromere binding factor 1 and two basic leucine zipper factors, Met4 and Met28, mediates the transcription activation of yeast sulfur metabolism. EMBO J 15(10):2519-29 SGD PMID 8665859
- ↑ Mellor J, et al. (1991) DNA binding of CPF1 is required for optimal centromere function but not for maintaining methionine prototrophy in yeast. Nucleic Acids Res 19(11):2961-9 SGD PMID 2057354
- ↑ Moreau JL, et al. (2003) Regulated displacement of TBP from the PHO8 promoter in vivo requires Cbf1 and the Isw1 chromatin remodeling complex. Mol Cell 11(6):1609-20 SGD PMID 12820973
- ↑ Wieland G, et al. (2001) Determination of the binding constants of the centromere protein Cbf1 to all 16 centromere DNAs of Saccharomyces cerevisiae. Nucleic Acids Res 29(5):1054-60 SGD PMID 11222754
- ↑ Zhou X and O'Shea EK (2011) Integrated Approaches Reveal Determinants of Genome-wide Binding and Function of the Transcription Factor Pho4. Mol Cell 42(6):826-36 SGD PMID 21700227
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