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Systematic name YJR047C
Gene name ANB1
Aliases HYP1, TIF51B, eIF-5A, eIF5A
Feature type ORF, Verified
Coordinates Chr X:525381..524908
Primary SGDID S000003808

Description of YJR047C: Translation elongation factor eIF-5A; previously thought to function in translation initiation; undergoes an essential hypusination modification; expressed under anaerobic conditions; ANB1 has a paralog, HYP2, that arose from the whole genome duplication[1][2][3][4][5]


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  1. Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 SGD PMID 16169922
  2. Kang HA, et al. (1993) Translation initiation factor eIF-5A, the hypusine-containing protein, is phosphorylated on serine in Saccharomyces cerevisiae. J Biol Chem 268(20):14750-6 SGD PMID 8325852
  3. Saini P, et al. (2009) Hypusine-containing protein eIF5A promotes translation elongation. Nature 459(7243):118-21 SGD PMID 19424157
  4. Schnier J, et al. (1991) Translation initiation factor 5A and its hypusine modification are essential for cell viability in the yeast Saccharomyces cerevisiae. Mol Cell Biol 11(6):3105-14 SGD PMID 1903841
  5. Schwelberger HG, et al. (1993) Translation initiation factor eIF-5A expressed from either of two yeast genes or from human cDNA. Functional identity under aerobic and anaerobic conditions. J Biol Chem 268(19):14018-25 SGD PMID 8314769

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