YJR017C
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| Systematic name | YJR017C |
| Gene name | ESS1 |
| Aliases | PIN1, PTF1 |
| Feature type | ORF, Verified |
| Coordinates | Chr X:467033..466521 |
| Primary SGDID | S000003778 |
Description of YJR017C: Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3[1][2][3]
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References
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- ↑ Hani J, et al. (1999) Mutations in a peptidylprolyl-cis/trans-isomerase gene lead to a defect in 3'-end formation of a pre-mRNA in Saccharomyces cerevisiae. J Biol Chem 274(1):108-16 SGD PMID 9867817
- ↑ Kops O, et al. (2002) Pin1 modulates the dephosphorylation of the RNA polymerase II C-terminal domain by yeast Fcp1. FEBS Lett 513(2-3):305-11 SGD PMID 11904169
- ↑ Ma Z, et al. (2012) Multiple Roles for the Ess1 Prolyl Isomerase in the RNA Polymerase II Transcription Cycle. Mol Cell Biol () SGD PMID 22778132
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