YJL184W

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Systematic name YJL184W
Gene name GON7
Aliases LDB6, PCC2
Feature type ORF, Verified
Coordinates Chr X:83448..83819
Primary SGDID S000003720


Description of YJL184W: Component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Bud32p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; implicated in osmotic stress response[1][2][3][4][5]




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References

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  1. Corbacho I, et al. (2004) Identification of low-dye-binding (ldb) mutants of Saccharomyces cerevisiae. FEMS Yeast Res 4(4-5):437-44 SGD PMID 14734024
  2. Downey M, et al. (2006) A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator. Cell 124(6):1155-68 SGD PMID 16564010
  3. Garay-Arroyo A, et al. (2000) Highly hydrophilic proteins in prokaryotes and eukaryotes are common during conditions of water deficit. J Biol Chem 275(8):5668-74 SGD PMID 10681550
  4. Kisseleva-Romanova E, et al. (2006) Yeast homolog of a cancer-testis antigen defines a new transcription complex. EMBO J 25(15):3576-85 SGD PMID 16874308
  5. Srinivasan M, et al. (2011) The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A. EMBO J 30(5):873-81 SGD PMID 21183954

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