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Systematic name YJL159W
Gene name HSP150
Aliases CCW7, ORE1, PIR2
Feature type ORF, Verified
Coordinates Chr X:120449..121690
Primary SGDID S000003695

Description of YJL159W: O-mannosylated heat shock protein that is secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation[1][2][3][4][5][6][7]


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  1. Ezaki B, et al. (1998) Protective roles of two aluminum (Al)-induced genes, HSP150 and SED1 of Saccharomyces cerevisiae, in Al and oxidative stresses. FEMS Microbiol Lett 159(1):99-105 SGD PMID 9485599
  2. Kapteyn JC, et al. (1999) The contribution of the O-glycosylated protein Pir2p/Hsp150 to the construction of the yeast cell wall in wild-type cells and beta 1,6-glucan-deficient mutants. Mol Microbiol 31(6):1835-44 SGD PMID 10209754
  3. Moukadiri I and Zueco J (2001) Evidence for the attachment of Hsp150/Pir2 to the cell wall of Saccharomyces cerevisiae through disulfide bridges. FEMS Yeast Res 1(3):241-5 SGD PMID 12702350
  4. Mrsa V and Tanner W (1999) Role of NaOH-extractable cell wall proteins Ccw5p, Ccw6p, Ccw7p and Ccw8p (members of the Pir protein family) in stability of the Saccharomyces cerevisiae cell wall. Yeast 15(10A):813-20 SGD PMID 10407261
  5. Russo P, et al. (1992) A heat shock gene from Saccharomyces cerevisiae encoding a secretory glycoprotein. Proc Natl Acad Sci U S A 89(9):3671-5 SGD PMID 1570286
  6. Russo P, et al. (1993) Dual regulation by heat and nutrient stress of the yeast HSP150 gene encoding a secretory glycoprotein. Mol Gen Genet 239(1-2):273-80 SGD PMID 8510655
  7. Toh-e A, et al. (1993) Three yeast genes, PIR1, PIR2 and PIR3, containing internal tandem repeats, are related to each other, and PIR1 and PIR2 are required for tolerance to heat shock. Yeast 9(5):481-94 SGD PMID 8322511

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