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Systematic name YJL115W
Gene name ASF1
Aliases CIA1
Feature type ORF, Verified
Coordinates Chr X:196287..197126
Primary SGDID S000003651

Description of YJL115W: Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition[1][2][3][4][5]


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  1. Nyswaner KM, et al. (2008) Chromatin-associated genes protect the yeast genome from ty1 insertional mutagenesis. Genetics 178(1):197-214 SGD PMID 18202368
  2. Osada S, et al. (2001) The yeast SAS (something about silencing) protein complex contains a MYST-type putative acetyltransferase and functions with chromatin assembly factor ASF1. Genes Dev 15(23):3155-68 SGD PMID 11731479
  3. Schwabish MA and Struhl K (2006) Asf1 mediates histone eviction and deposition during elongation by RNA polymerase II. Mol Cell 22(3):415-22 SGD PMID 16678113
  4. Singer MS, et al. (1998) Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae. Genetics 150(2):613-32 SGD PMID 9755194
  5. Tyler JK, et al. (1999) The RCAF complex mediates chromatin assembly during DNA replication and repair. Nature 402(6761):555-60 SGD PMID 10591219

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