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Systematic name YJL050W
Gene name MTR4
Aliases DOB1
Feature type ORF, Verified
Coordinates Chr X:342522..345743
Primary SGDID S000003586

Description of YJL050W: ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing[1][2][3][4][5][6][7][8][9][10]


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  1. Bernstein J, et al. (2008) Characterization of the Essential Activities of Saccharomyces cerevisiae Mtr4p, a 3'->5' Helicase Partner of the Nuclear Exosome. J Biol Chem 283(8):4930-42 SGD PMID 18096702
  2. Jackson RN, et al. (2010) The crystal structure of Mtr4 reveals a novel arch domain required for rRNA processing. EMBO J 29(13):2205-16 SGD PMID 20512111
  3. Jia H, et al. (2012) RNA unwinding by the Trf4/Air2/Mtr4 polyadenylation (TRAMP) complex. Proc Natl Acad Sci U S A 109(19):7292-7 SGD PMID 22532666
  4. LaCava J, et al. (2005) RNA degradation by the exosome is promoted by a nuclear polyadenylation complex. Cell 121(5):713-24 SGD PMID 15935758
  5. Lebreton A and Seraphin B (2008) Exosome-mediated quality control: substrate recruitment and molecular activity. Biochim Biophys Acta 1779(9):558-65 SGD PMID 18313413
  6. Vanacova S, et al. (2005) A new yeast poly(A) polymerase complex involved in RNA quality control. PLoS Biol 3(6):e189 SGD PMID 15828860
  7. Wang X, et al. (2008) Degradation of hypomodified tRNA(iMet) in vivo involves RNA-dependent ATPase activity of the DExH helicase Mtr4p. RNA 14(1):107-16 SGD PMID 18000032
  8. Weir JR, et al. (2010) Structural analysis reveals the characteristic features of Mtr4, a DExH helicase involved in nuclear RNA processing and surveillance. Proc Natl Acad Sci U S A 107(27):12139-44 SGD PMID 20566885
  9. Wyers F, et al. (2005) Cryptic pol II transcripts are degraded by a nuclear quality control pathway involving a new poly(A) polymerase. Cell 121(5):725-37 SGD PMID 15935759
  10. de la Cruz J, et al. (1998) Dob1p (Mtr4p) is a putative ATP-dependent RNA helicase required for the 3' end formation of 5.8S rRNA in Saccharomyces cerevisiae. EMBO J 17(4):1128-40 SGD PMID 9463390

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