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Systematic name YIR006C
Gene name PAN1
Aliases DIM2, MDP3, MIP3
Feature type ORF, Verified
Coordinates Chr IX:369908..365466
Primary SGDID S000001445

Description of YIR006C: Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; binds to and activates the Arp2/3 complex in vitro; previously thought to be a subunit of poly(A) ribonuclease[1][2][3][4]


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  1. Duncan MC, et al. (2001) Yeast Eps15-like endocytic protein, Pan1p, activates the Arp2/3 complex. Nat Cell Biol 3(7):687-90 SGD PMID 11433303
  2. Tang HY and Cai M (1996) The EH-domain-containing protein Pan1 is required for normal organization of the actin cytoskeleton in Saccharomyces cerevisiae. Mol Cell Biol 16(9):4897-914 SGD PMID 8756649
  3. Wendland B, et al. (1996) A novel fluorescence-activated cell sorter-based screen for yeast endocytosis mutants identifies a yeast homologue of mammalian eps15. J Cell Biol 135(6 Pt 1):1485-500 SGD PMID 8978817
  4. Zeng G, et al. (2001) Regulation of yeast actin cytoskeleton-regulatory complex Pan1p/Sla1p/End3p by serine/threonine kinase Prk1p. Mol Biol Cell 12(12):3759-72 SGD PMID 11739778

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