YIL153W
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| Systematic name | YIL153W |
| Gene name | RRD1 |
| Aliases | YPA1 |
| Feature type | ORF, Verified |
| Coordinates | Chr IX:55198..56379 |
| Primary SGDID | S000001415 |
Description of YIL153W: Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex[1][2][3][4][5][6][7][8][9][10]
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References
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- ↑ Douville J, et al. (2004) The yeast phosphotyrosyl phosphatase activator protein, yPtpa1/Rrd1, interacts with Sit4 phosphatase to mediate resistance to 4-nitroquinoline-1-oxide and UVA. Curr Genet 46(2):72-81 SGD PMID 15150670
- ↑ Fellner T, et al. (2003) A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo. Genes Dev 17(17):2138-50 SGD PMID 12952889
- ↑ Jordens J, et al. (2006) The protein phosphatase 2A phosphatase activator is a novel peptidyl-prolyl cis/trans-isomerase. J Biol Chem 281(10):6349-57 SGD PMID 16380387
- ↑ Marrakchi R, et al. (2011) The isomerase Rrd1 mediates rapid loss of the Sgs1 helicase in response to rapamycin. Biochem Cell Biol () SGD PMID 21639830
- ↑ Mitchell DA and Sprague GF Jr (2001) The phosphotyrosyl phosphatase activator, Ncs1p (Rrd1p), functions with Cla4p to regulate the G(2)/M transition in Saccharomyces cerevisiae. Mol Cell Biol 21(2):488-500 SGD PMID 11134337
- ↑ Rempola B, et al. (2000) Functional analysis of RRD1 (YIL153w) and RRD2 (YPL152w), which encode two putative activators of the phosphotyrosyl phosphatase activity of PP2A in Saccharomyces cerevisiae. Mol Gen Genet 262(6):1081-92 SGD PMID 10660069
- ↑ Van Hoof C, et al. (1998) Functional analysis of conserved domains in the phosphotyrosyl phosphatase activator. Molecular cloning of the homologues from Drosophila melanogaster and Saccharomyces cerevisiae. Biochemistry 37(37):12899-908 SGD PMID 9737869
- ↑ Van Hoof C, et al. (2000) The Saccharomyces cerevisiae homologue YPA1 of the mammalian phosphotyrosyl phosphatase activator of protein phosphatase 2A controls progression through the G1 phase of the yeast cell cycle. J Mol Biol 302(1):103-20 SGD PMID 10964564
- ↑ Van Hoof C, et al. (2001) The Saccharomyces cerevisiae phosphotyrosyl phosphatase activator proteins are required for a subset of the functions disrupted by protein phosphatase 2A mutations. Exp Cell Res 264(2):372-87 SGD PMID 11262194
- ↑ Zheng Y and Jiang Y (2005) The yeast phosphotyrosyl phosphatase activator is part of the Tap42-phosphatase complexes. Mol Biol Cell 16(4):2119-27 SGD PMID 15689491
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