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Systematic name YIL110W
Gene name HPM1
Aliases MNI1
Feature type ORF, Verified
Coordinates Chr IX:156045..157178
Primary SGDID S000001372

Description of YIL110W: AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance[1][2][3][4]


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  1. Bonangelino CJ, et al. (2002) Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Mol Biol Cell 13(7):2486-501 SGD PMID 12134085
  2. Katz JE, et al. (2003) Automated identification of putative methyltransferases from genomic open reading frames. Mol Cell Proteomics 2(8):525-40 SGD PMID 12872006
  3. Lesage G, et al. (2004) Analysis of beta-1,3-glucan assembly in Saccharomyces cerevisiae using a synthetic interaction network and altered sensitivity to caspofungin. Genetics 167(1):35-49 SGD PMID 15166135
  4. Webb KJ, et al. (2010) A Novel 3-Methylhistidine Modification of Yeast Ribosomal Protein Rpl3 Is Dependent upon the YIL110W Methyltransferase. J Biol Chem 285(48):37598-606 SGD PMID 20864530

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