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Systematic name YHR189W
Gene name PTH1
Aliases PTH
Feature type ORF, Verified
Coordinates Chr VIII:484028..484600
Primary SGDID S000001232

Description of YHR189W: One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium[1][2][3][4][5]


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  1. Fromant M, et al. (2003) Peptidyl-tRNA hydrolase from Sulfolobus solfataricus. Nucleic Acids Res 31(12):3227-35 SGD PMID 12799450
  2. Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 SGD PMID 14562095
  3. Menez J, et al. (2002) Peptidyl-tRNA hydrolase in Bacillus subtilis, encoded by spoVC, is essential to vegetative growth, whereas the homologous enzyme in Saccharomyces cerevisiae is dispensable. Mol Microbiol 45(1):123-9 SGD PMID 12100553
  4. Rosas-Sandoval G, et al. (2002) Orthologs of a novel archaeal and of the bacterial peptidyl-tRNA hydrolase are nonessential in yeast. Proc Natl Acad Sci U S A 99(26):16707-12 SGD PMID 12475929
  5. Sickmann A, et al. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12 SGD PMID 14576278

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