YHR187W

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Systematic name YHR187W
Gene name IKI1
Aliases ELP5, HAP2, TOT5
Feature type ORF, Verified
Coordinates Chr VIII:480990..481919
Primary SGDID S000001230


Description of YHR187W: Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin[1][2][3][4]




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References

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  1. Esberg A, et al. (2006) Elevated levels of two tRNA species bypass the requirement for elongator complex in transcription and exocytosis. Mol Cell 24(1):139-48 SGD PMID 17018299
  2. Frohloff F, et al. (2003) Subunit communications crucial for the functional integrity of the yeast RNA polymerase II elongator (gamma-toxin target (TOT)) complex. J Biol Chem 278(2):956-61 SGD PMID 12424236
  3. Glatt S, et al. (2012) The Elongator subcomplex Elp456 is a hexameric RecA-like ATPase.LID - 10.1038/nsmb.2234 [doi] Nat Struct Mol Biol () SGD PMID 22343726
  4. Kishida M, et al. (1996) Isolation and genetic characterization of pGKL killer-insensitive mutants (iki) from Saccharomyces cerevisiae. Biosci Biotechnol Biochem 60(5):798-801 SGD PMID 8704309

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