YHR154W
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| Systematic name | YHR154W |
| Gene name | RTT107 |
| Aliases | ESC4 |
| Feature type | ORF, Verified |
| Coordinates | Chr VIII:402966..406178 |
| Primary SGDID | S000001197 |
Description of YHR154W: Protein implicated in Mms22-dependent DNA repair during S phase; involved in recruiting the SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition[1][2][3][4][5]
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References
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- ↑ Baldwin EL, et al. (2005) Mms22p protects Saccharomyces cerevisiae from DNA damage induced by topoisomerase II. Nucleic Acids Res 33(3):1021-30 SGD PMID 15718301
- ↑ Leung GP, et al. (2011) Rtt107 is required for recruitment of the SMC5/6 complex to DNA double-strand breaks. J Biol Chem () SGD PMID 21642432
- ↑ Roberts TM, et al. (2006) Slx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4. Mol Biol Cell 17(1):539-48 SGD PMID 16267268
- ↑ Rouse J (2004) Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage. EMBO J 23(5):1188-97 SGD PMID 14988729
- ↑ Scholes DT, et al. (2001) Multiple regulators of Ty1 transposition in Saccharomyces cerevisiae have conserved roles in genome maintenance. Genetics 159(4):1449-65 SGD PMID 11779788
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