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Systematic name YHR149C
Gene name SKG6
Feature type ORF, Verified
Coordinates Chr VIII:396659..394455
Primary SGDID S000001192

Description of YHR149C: Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p[1][2][3][4]


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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [4] [5]

Transmembrane Domain GxxxG-like motif

The transmembrane domain of this protein contains GvavAvpvG. The presence of multiple, chained GxxxG-like motifs [6] strongly indicates that Skg6p dimerises.



See Help:References on how to add references

  1. Drees BL, et al. (2001) A protein interaction map for cell polarity development. J Cell Biol 154(3):549-71 SGD PMID 11489916
  2. Tomishige N, et al. (2005) SKG1, a suppressor gene of synthetic lethality of kex2Deltagas1Delta mutations, encodes a novel membrane protein that affects cell wall composition. Yeast 22(2):141-55 SGD PMID 15645486
  3. Tomishige N, et al. (2005) SKG6, a suppressor gene of synthetic lethality of kex2Delta gas1Delta mutations, encodes a novel membrane protein showing polarized intracellular localization. J Gen Appl Microbiol 51(5):323-6 SGD PMID 16314687
  4. 4.0 4.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415 Cite error: Invalid <ref> tag; name "S000074306" defined multiple times with different content
  5. submitted by Jeff Ubersax on 2004-01-27
  6. Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242

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