YHR086W
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| Systematic name | YHR086W |
| Gene name | NAM8 |
| Aliases | MRE2, MUD15 |
| Feature type | ORF, Verified |
| Coordinates | Chr VIII:278153..279724 |
| Primary SGDID | S000001128 |
Description of YHR086W: RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function[1][2][3][4]
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References
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- ↑ Nakagawa T and Ogawa H (1997) Involvement of the MRE2 gene of yeast in formation of meiosis-specific double-strand breaks and crossover recombination through RNA splicing. Genes Cells 2(1):65-79 SGD PMID 9112441
- ↑ Ogawa H, et al. (1995) Functions of the yeast meiotic recombination genes, MRE11 and MRE2. Adv Biophys 31:67-76 SGD PMID 7625279
- ↑ Puig O, et al. (1999) Interaction of the U1 snRNP with nonconserved intronic sequences affects 5' splice site selection. Genes Dev 13(5):569-80 SGD PMID 10072385
- ↑ Qiu ZR, et al. (2011) Defining the Mer1 and Nam8 meiotic splicing regulons by cDNA rescue. RNA () SGD PMID 21788335
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