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Systematic name YGR142W
Gene name BTN2
Feature type ORF, Verified
Coordinates Chr VII:772454..773686
Primary SGDID S000003374

Description of YGR142W: v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; BTN2 has a paralog, CUR1, that arose from the whole genome duplication[1][2][3][4][5]


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  1. Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 SGD PMID 16169922
  2. Chattopadhyay S and Pearce DA (2002) Interaction with Btn2p is required for localization of Rsglp: Btn2p-mediated changes in arginine uptake in Saccharomyces cerevisiae. Eukaryot Cell 1(4):606-12 SGD PMID 12456008
  3. Chattopadhyay S, et al. (2000) The yeast model for batten disease: mutations in BTN1, BTN2, and HSP30 alter pH homeostasis. J Bacteriol 182(22):6418-23 SGD PMID 11053386
  4. Chattopadhyay S, et al. (2003) The yeast model for Batten disease: a role for Btn2p in the trafficking of the Golgi-associated vesicular targeting protein, Yif1p. Biochem Biophys Res Commun 302(3):534-8 SGD PMID 12615067
  5. Kama R, et al. (2007) Btn2, a hook1 ortholog and potential batten disease-related protein, mediates late endosome-Golgi protein sorting in yeast. Mol Cell Biol 27(2):605-21 SGD PMID 17101785

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