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Systematic name YGR133W
Gene name PEX4
Aliases PAS2, UBC10
Feature type ORF, Verified
Coordinates Chr VII:756896..757447
Primary SGDID S000003365

Description of YGR133W: Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis[1][2][3][4]


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Protein Details

Other Protein Details

Other Topic: Homology

Homology was found, at the sequence and domain-composition level, between several components of the Peroxisomal protein import machinery and components of the Endoplasmic Reticulum Associated Decay (ERAD) pathway. This suggests a common evolutionary origin for both systems and a similar mechanism of action. The homology relationships can be stablished between Pex1,Pex6 and cdc48; Pex2 and Hrd1; Pex4 and Ubc1; and Pex5 and Hrd3. [5] [6]



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  1. Eckert JH and Johnsson N (2003) Pex10p links the ubiquitin conjugating enzyme Pex4p to the protein import machinery of the peroxisome. J Cell Sci 116(Pt 17):3623-34 SGD PMID 12876220
  2. Erdmann R, et al. (1989) Isolation of peroxisome-deficient mutants of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 86(14):5419-23 SGD PMID 2568633
  3. Kragt A, et al. (2005) The Saccharomyces cerevisiae peroxisomal import receptor Pex5p is monoubiquitinated in wild type cells. J Biol Chem 280(9):7867-74 SGD PMID 15632140
  4. Wiebel FF and Kunau WH (1992) The Pas2 protein essential for peroxisome biogenesis is related to ubiquitin-conjugating enzymes. Nature 359(6390):73-6 SGD PMID 1326082
  5. Gabaldon T, et al. (2006) Origin and evolution of the peroxisomal proteome. Biol Direct 1():8 SGD PMID 16556314
  6. submitted by Toni Gabaldon on 2006-04-12

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