YGR112W
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| Systematic name | YGR112W |
| Gene name | SHY1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:717358..718527 |
| Primary SGDID | S000003344 |
Description of YGR112W: Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome[1][2][3]
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References
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- Jump up ↑ Barrientos A, et al. (2002) Shy1p is necessary for full expression of mitochondrial COX1 in the yeast model of Leigh's syndrome. EMBO J 21(1-2):43-52 SGD PMID 11782424
- Jump up ↑ Mashkevich G, et al. (1997) SHY1, the yeast homolog of the mammalian SURF-1 gene, encodes a mitochondrial protein required for respiration. J Biol Chem 272(22):14356-64 SGD PMID 9162072
- Jump up ↑ Mick DU, et al. (2007) Shy1 couples Cox1 translational regulation to cytochrome c oxidase assembly. EMBO J 26(20):4347-58 SGD PMID 17882259
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