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Systematic name YGR024C
Gene name THG1
Feature type ORF, Verified
Coordinates Chr VII:532596..531883
Primary SGDID S000003256

Description of YGR024C: tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes[1][2]


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  1. Gu W, et al. (2003) tRNAHis maturation: an essential yeast protein catalyzes addition of a guanine nucleotide to the 5' end of tRNAHis. Genes Dev 17(23):2889-901 SGD PMID 14633974
  2. Rice TS, et al. (2005) The highly conserved tRNAHis guanylyltransferase Thg1p interacts with the origin recognition complex and is required for the G2/M phase transition in the yeast Saccharomyces cerevisiae. Eukaryot Cell 4(4):832-5 SGD PMID 15821142

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