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Systematic name YGL237C
Gene name HAP2
Feature type ORF, Verified
Coordinates Chr VII:53528..52731
Primary SGDID S000003206

Description of YGL237C: Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding[1][2][3][4][5]


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  1. Chodosh LA, et al. (1988) A yeast and a human CCAAT-binding protein have heterologous subunits that are functionally interchangeable. Cell 53(1):25-35 SGD PMID 3280141
  2. Forsburg SL and Guarente L (1989) Identification and characterization of HAP4: a third component of the CCAAT-bound HAP2/HAP3 heteromer. Genes Dev 3(8):1166-78 SGD PMID 2676721
  3. Olesen JT and Guarente L (1990) The HAP2 subunit of yeast CCAAT transcriptional activator contains adjacent domains for subunit association and DNA recognition: model for the HAP2/3/4 complex. Genes Dev 4(10):1714-29 SGD PMID 2123465
  4. Pinkham JL and Guarente L (1985) Cloning and molecular analysis of the HAP2 locus: a global regulator of respiratory genes in Saccharomyces cerevisiae. Mol Cell Biol 5(12):3410-6 SGD PMID 3915775
  5. Pinkham JL, et al. (1987) Sequence and nuclear localization of the Saccharomyces cerevisiae HAP2 protein, a transcriptional activator. Mol Cell Biol 7(2):578-85 SGD PMID 3547076

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