YGL173C
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| Systematic name | YGL173C |
| Gene name | XRN1 |
| Aliases | DST2, KEM1, RAR5, SEP1, SKI1 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:180113..175527 |
| Primary SGDID | S000003141 |
Description of YGL173C: Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance; activated by the scavenger decapping enzyme Dcs1p[1][2][3][4][5][6][7]
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References
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- ↑ Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 SGD PMID 15161972
- ↑ Geerlings TH, et al. (2000) The final step in the formation of 25S rRNA in Saccharomyces cerevisiae is performed by 5'-->3' exonucleases. RNA 6(12):1698-703 SGD PMID 11142370
- ↑ Kim J and Kim J (2002) KEM1 is involved in filamentous growth of Saccharomyces cerevisiae. FEMS Microbiol Lett 216(1):33-8 SGD PMID 12423748
- ↑ Larimer FW and Stevens A (1990) Disruption of the gene XRN1, coding for a 5'----3' exoribonuclease, restricts yeast cell growth. Gene 95(1):85-90 SGD PMID 1979303
- ↑ Sheth U and Parker R (2003) Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300(5620):805-8 SGD PMID 12730603
- ↑ Sinturel F, et al. (2012) Activation of 5'-3' exoribonuclease Xrn1 by cofactor Dcs1 is essential for mitochondrial function in yeast. Proc Natl Acad Sci U S A () SGD PMID 22570495
- ↑ Solinger JA, et al. (1999) Active-site mutations in the Xrn1p exoribonuclease of Saccharomyces cerevisiae reveal a specific role in meiosis. Mol Cell Biol 19(9):5930-42 SGD PMID 10454540
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