YGL145W

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Systematic name YGL145W
Gene name TIP20
Aliases TIP1
Feature type ORF, Verified
Coordinates Chr VII:230243..232348
Primary SGDID S000003113


Description of YGL145W: Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p[1][2]




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References

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  1. Kamena F and Spang A (2004) Tip20p prohibits back-fusion of COPII vesicles with the endoplasmic reticulum. Science 304(5668):286-9 SGD PMID 15073376
  2. Tripathi A, et al. (2009) Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex. Nat Struct Mol Biol 16(2):114-23 SGD PMID 19151722

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