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Systematic name YGL127C
Gene name SOH1
Aliases MED31
Feature type ORF, Verified
Coordinates Chr VII:270775..270392
Primary SGDID S000003095

Description of YGL127C: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits[1][2][3][4]


Community Commentary

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DNA and RNA Details

Other DNA and RNA Details

Other Topic: expression

Specifically higher expression in sulfur limited chemostat cultures versus sulfur excess. [5] [6]

Protein Details

Protein Function/Process

Subunit of the Mediator complex essential for transcriptional regulation [4] [7]



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  1. Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 SGD PMID 15161972
  2. Bourbon HM, et al. (2004) A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell 14(5):553-7 SGD PMID 15175151
  3. Guglielmi B, et al. (2004) A high resolution protein interaction map of the yeast Mediator complex. Nucleic Acids Res 32(18):5379-91 SGD PMID 15477388
  4. 4.0 4.1 Linder T and Gustafsson CM (2004) The Soh1/MED31 protein is an ancient component of Schizosaccharomyces pombe and Saccharomyces cerevisiae Mediator. J Biol Chem 279(47):49455-9 SGD PMID 15356001 Cite error: Invalid <ref> tag; name "S000079700" defined multiple times with different content
  5. Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
  6. submitted by Viktor Boer on 2003-07-25
  7. submitted by Tomas Linder on 2005-06-08

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