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Systematic name YGL080W
Gene name FMP37
Aliases MPC1
Feature type ORF, Verified
Coordinates Chr VII:358636..359028
Primary SGDID S000003048

Description of YGL080W: Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog is associated with lactic acidosis and hyperpyruvatemia[1][2][3][4]


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DNA and RNA Details

Other DNA and RNA Details

Other Topic: expression

Specifically higher expression in carbon limited chemostat cultures versus carbon excess. [5] [6]



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  1. Bricker DK, et al. (2012) A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans. Science () SGD PMID 22628558
  2. Heinicke S, et al. (2007) The Princeton Protein Orthology Database (P-POD): a comparative genomics analysis tool for biologists. PLoS One 2(8):e766 SGD PMID 17712414
  3. Herzig S, et al. (2012) Identification and Functional Expression of the Mitochondrial Pyruvate Carrier. Science () SGD PMID 22628554
  4. Reinders J, et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD PMID 16823961
  5. Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
  6. submitted by Viktor Boer on 2003-07-25

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