YGL080W
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| Systematic name | YGL080W |
| Gene name | FMP37 |
| Aliases | MPC1 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:358636..359028 |
| Primary SGDID | S000003048 |
Description of YGL080W: Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog is associated with lactic acidosis and hyperpyruvatemia[1][2][3][4]
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DNA and RNA Details
Other DNA and RNA Details
Other Topic: expression
Specifically higher expression in carbon limited chemostat cultures versus carbon excess. [5] [6]
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References
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- Jump up ↑ Bricker DK, et al. (2012) A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans. Science () SGD PMID 22628558
- Jump up ↑ Heinicke S, et al. (2007) The Princeton Protein Orthology Database (P-POD): a comparative genomics analysis tool for biologists. PLoS One 2(8):e766 SGD PMID 17712414
- Jump up ↑ Herzig S, et al. (2012) Identification and Functional Expression of the Mitochondrial Pyruvate Carrier. Science () SGD PMID 22628554
- Jump up ↑ Reinders J, et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD PMID 16823961
- Jump up ↑ Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
- Jump up ↑ submitted by Viktor Boer on 2003-07-25
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