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Systematic name YFR055W
Gene name IRC7
Feature type ORF, Uncharacterized
Coordinates Chr VI:264204..265226
Primary SGDID S000001952

Description of YFR055W: Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner[1][2][3][4][5]


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DNA and RNA Details

Other DNA and RNA Details

Other Topic: expression

Specifically higher expression in nitrogen limited chemostat cultures versus nitrogen excess. [6] [7]


Gene Origin

Horizontally transferred from gamma proteobacteria [8] [9]



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  1. Alvaro D, et al. (2007) Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination. PLoS Genet 3(12):e228 SGD PMID 18085829
  2. Gross C, et al. (2000) Identification of the copper regulon in Saccharomyces cerevisiae by DNA microarrays. J Biol Chem 275(41):32310-6 SGD PMID 10922376
  3. Hansen J and Johannesen PF (2000) Cysteine is essential for transcriptional regulation of the sulfur assimilation genes in Saccharomyces cerevisiae. Mol Gen Genet 263(3):535-42 SGD PMID 10821189
  4. Roncoroni M, et al. (2011) The yeast IRC7 gene encodes a beta-lyase responsible for production of the varietal thiol 4-mercapto-4-methylpentan-2-one in wine. Food Microbiol 28(5):926-35 SGD PMID 21569935
  5. Scherens B, et al. (2006) Identification of direct and indirect targets of the Gln3 and Gat1 activators by transcriptional profiling in response to nitrogen availability in the short and long term. FEMS Yeast Res 6(5):777-91 SGD PMID 16879428
  6. Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
  7. submitted by Viktor Boer on 2003-07-25
  8. Hall C, et al. (2005) Contribution of horizontal gene transfer to the evolution of Saccharomyces cerevisiae. Eukaryot Cell 4(6):1102-15 SGD PMID 15947202
  9. submitted by Charles Hall on 2006-06-09

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