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Systematic name YER179W
Gene name DMC1
Aliases ISC2
Feature type ORF, Verified
Coordinates Chr V:548421..549517
Primary SGDID S000000981

Description of YER179W: Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein; binds ssDNA and dsDNA, forms helical filaments; stimulated by Rdh54p[1][2][3][4]


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  1. Bishop DK, et al. (1992) DMC1: a meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression. Cell 69(3):439-56 SGD PMID 1581960
  2. Nimonkar AV, et al. (2012) Saccharomyces cerevisiae Dmc1 and Rad51 preferentially function with Tid1 and Rad54, respectively, to promote DNA strand invasion during genetic recombination. J Biol Chem () SGD PMID 22761450
  3. Schwacha A and Kleckner N (1997) Interhomolog bias during meiotic recombination: meiotic functions promote a highly differentiated interhomolog-only pathway. Cell 90(6):1123-35 SGD PMID 9323140
  4. Symington LS (2002) Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair. Microbiol Mol Biol Rev 66(4):630-70, table of contents SGD PMID 12456786

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