YER175C

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Systematic name YER175C
Gene name TMT1
Aliases TAM1
Feature type ORF, Verified
Coordinates Chr V:540363..539464
Primary SGDID S000000977


Description of YER175C: Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle[1][2]




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References

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  1. Cai H, et al. (2001) Identification of the gene and characterization of the activity of the trans-aconitate methyltransferase from Saccharomyces cerevisiae. Biochemistry 40(45):13699-709 SGD PMID 11695919
  2. Katz JE, et al. (2004) 3-Isopropylmalate is the major endogenous substrate of the Saccharomyces cerevisiae trans-aconitate methyltransferase. Biochemistry 43(20):5976-86 SGD PMID 15147181

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