YER164W

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Systematic name YER164W
Gene name CHD1
Aliases
Feature type ORF, Verified
Coordinates Chr V:505392..509798
Primary SGDID S000000966


Description of YER164W: Chromatin remodeler that regulates various aspects of transcription; acts in in conjunction with Isw1b to regulate chromatin structure and maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes[1][2][3][4][5]




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References

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  1. Pray-Grant MG, et al. (2005) Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation. Nature 433(7024):434-8 SGD PMID 15647753
  2. Simic R, et al. (2003) Chromatin remodeling protein Chd1 interacts with transcription elongation factors and localizes to transcribed genes. EMBO J 22(8):1846-56 SGD PMID 12682017
  3. Smolle M, et al. (2012) Chromatin remodelers Isw1 and Chd1 maintain chromatin structure during transcription by preventing histone exchange.LID - 10.1038/nsmb.2312 [doi] Nat Struct Mol Biol () SGD PMID 22922743
  4. Tran HG, et al. (2000) The chromo domain protein chd1p from budding yeast is an ATP-dependent chromatin-modifying factor. EMBO J 19(10):2323-31 SGD PMID 10811623
  5. Woodage T, et al. (1997) Characterization of the CHD family of proteins. Proc Natl Acad Sci U S A 94(21):11472-7 SGD PMID 9326634

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