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Systematic name YDR454C
Gene name GUK1
Aliases PUR5
Feature type ORF, Verified
Coordinates Chr IV:1366827..1366264
Primary SGDID S000002862

Description of YDR454C: Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins[1][2][3]


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  1. Berger A, et al. (1989) Guanylate kinase from Saccharomyces cerevisiae. Isolation and characterization, crystallization and preliminary X-ray analysis, amino acid sequence and comparison with adenylate kinases. Eur J Biochem 184(2):433-43 SGD PMID 2551688
  2. Konrad M (1992) Cloning and expression of the essential gene for guanylate kinase from yeast. J Biol Chem 267(36):25652-5 SGD PMID 1334480
  3. Shimma Y, et al. (1997) A defect in GTP synthesis affects mannose outer chain elongation in Saccharomyces cerevisiae. Mol Gen Genet 256(5):469-80 SGD PMID 9413430

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