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Systematic name YDR443C
Gene name SSN2
Aliases MED13, NUT8, RYE3, SCA1, SRB9, UME2
Feature type ORF, Verified
Coordinates Chr IV:1349938..1345676
Primary SGDID S000002851

Description of YDR443C: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation[1][2][3]


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  1. Carlson M, et al. (1984) A suppressor of SNF1 mutations causes constitutive high-level invertase synthesis in yeast. Genetics 107(1):19-32 SGD PMID 6373495
  2. Larschan E and Winston F (2005) The Saccharomyces cerevisiae Srb8-Srb11 complex functions with the SAGA complex during Gal4-activated transcription. Mol Cell Biol 25(1):114-23 SGD PMID 15601835
  3. Song W, et al. (1996) SSN genes that affect transcriptional repression in Saccharomyces cerevisiae encode SIN4, ROX3, and SRB proteins associated with RNA polymerase II. Mol Cell Biol 16(1):115-20 SGD PMID 8524287

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