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Systematic name YDR363W-A
Gene name SEM1
Aliases DSS1, HOD1
Feature type ORF, Verified
Coordinates Chr IV:1202128..1202397
Primary SGDID S000007235

Description of YDR363W-A: Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1[1][2][3][4]


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  1. Funakoshi M, et al. (2004) Sem1, the yeast ortholog of a human BRCA2-binding protein, is a component of the proteasome regulatory particle that enhances proteasome stability. J Cell Sci 117(Pt 26):6447-54 SGD PMID 15572408
  2. Jantti J, et al. (1999) SEM1, a homologue of the split hand/split foot malformation candidate gene Dss1, regulates exocytosis and pseudohyphal differentiation in yeast. Proc Natl Acad Sci U S A 96(3):909-14 SGD PMID 9927667
  3. Sone T, et al. (2004) Sem1p is a novel subunit of the 26 S proteasome from Saccharomyces cerevisiae. J Biol Chem 279(27):28807-16 SGD PMID 15117943
  4. Wilmes GM, et al. (2008) A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing. Mol Cell 32(5):735-46 SGD PMID 19061648

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