YDR356W

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Systematic name YDR356W
Gene name SPC110
Aliases NUF1, XCM1
Feature type ORF, Verified
Coordinates Chr IV:1186107..1188941
Primary SGDID S000002764


Description of YDR356W: Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner[1][2][3][4][5]




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References

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  1. Flory MR, et al. (2000) Identification of a human centrosomal calmodulin-binding protein that shares homology with pericentrin. Proc Natl Acad Sci U S A 97(11):5919-23 SGD PMID 10823944
  2. Friedman DB, et al. (2001) Yeast Mps1p phosphorylates the spindle pole component Spc110p in the N-terminal domain. J Biol Chem 276(21):17958-67 SGD PMID 11278681
  3. Geiser JR, et al. (1993) The essential mitotic target of calmodulin is the 110-kilodalton component of the spindle pole body in Saccharomyces cerevisiae. Mol Cell Biol 13(12):7913-24 SGD PMID 8247006
  4. Knop M and Schiebel E (1997) Spc98p and Spc97p of the yeast gamma-tubulin complex mediate binding to the spindle pole body via their interaction with Spc110p. EMBO J 16(23):6985-95 SGD PMID 9384578
  5. Mirzayan C, et al. (1992) The NUF1 gene encodes an essential coiled-coil related protein that is a potential component of the yeast nucleoskeleton. J Cell Biol 116(6):1319-32 SGD PMID 1541631

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